Luigi Infantino (April 24, 1921, Racalmuto – June 22, 1991, Rome) was an Italian operatic tenor, particularly associated with the lyric Italian and French repertories.

Luigi Infantino studied at the Parma Conservatory with Italo Brancucci. He made his debut in 1943, at the Teatro Regio in Parma, as Rodolfo in La bohème, which was also his debut role at the Teatro San Carlo in Naples, in 1945. With [bad word]  he appeared in London as the Duke in Rigoletto, and Rodolfo.